Windows 10 is very different from previous versions of Windows. Windows 10 will make regular incremental improvements to the operating system. Some of these changes might not be desirable in a mission critical system. Because of this, the Windows 10 Enterprise Long-Term Servicing Branch (LTSB) Edition is worth consideration.
“For critical or specialized devices (for example, operation of factory floor machinery, point-of-sale systems, automated teller machines), the Long-Term Servicing Branch (LTSB) provides a version of Windows 10 Enterprise that receives no new features, while continuing to be supported with security and other updates for a long time. (Note that the Long-Term Servicing Branch is a separate Windows 10 Enterprise image, with many in-box apps, including Microsoft Edge, Cortana, and Windows Store, removed.)” Michael Niehaus, Microsoft TechNet: Windows 10 servicing options
As the Microsoft TechNet article explains, the Windows 10 Enterprise LTSB Edition is recommended for a mission critical system using Windows 10 in Retail, Manufacturing and Pharmaceutical. Secure Desktop is designed for these same industries.
Secure Desktop has always been designed for what is now called a Classic Windows application (CWA). These applications run on what is now called the Classic Windows Platform (CWP) (e.g., COM, Win32, WPF, WinForms, etc.).
A Universal Windows app (UWA) is a new kind of app for Windows 10 and is built to run on the Universal Windows Platform (UWP).
The Classic Windows Platform exists as a series of services, usually exe and dll files, that run independently of the Windows Explorer shell. The Windows Explorer shell and the Secure Desktop shell both provide the ability to run Classic Windows applications.
In Windows 10, the Universal Windows Platform is an integral part of the Windows Explorer shell. The Windows Explorer shell has to be running to launch and run a Universal Windows app. This is an unfortunate architectural choice.
Secure Desktop provides security by replacing the Windows Explorer shell. When Secure Desktop is set as the Windows shell, the Explorer shell is not running. Because the Explorer shell is not running, Secure Desktop can not run Universal Windows apps in any Edition of Windows 10.
Secure Desktop has always been able to launch browsers that are designed as Classic Windows applications (CWA) such as Internet Explorer, Chrome, Firefox and Opera. We have specific features for Internet Explorer 11. Other CWA browsers will simply run "as is" or may be controlled slightly using the Windows Wizard.
Secure Desktop can not launch browsers that are designed as Universal Windows applications (UWA) such as Microsoft Edge.
Although Secure Desktop 10 may be used on any Edition of Windows 10, we strongly recommend consideration of the Windows 10 Enterprise LTSB Edition before making a final decision. Regardless of what Edition of Windows 10 you choose, Secure Desktop can not run Universal Windows apps. Based on our research we believe that Windows 10 Enterprise LTSB Edition may be the most secure and stable in a mission critical system.